PICA Arduino Due compatibility


I’m starting to bump into the limits of 8bit controllers and I’m wondering if the PICA is compatible with the Arduino Due 32bit controller. The Due is 3.3v and the 2560 is 5v. I’m not very well versed on what that means or how it would be mitigated.

I’ve seen in another thread that the RE-ARM controller might be an option as well.